ALassoSurvIC - Adaptive Lasso for the Cox Regression with Interval Censored and Possibly Left Truncated Data

Penalized variable selection tools for the Cox proportional hazards model with interval censored and possibly left truncated data. It performs variable selection via penalized nonparametric maximum likelihood estimation with an adaptive lasso penalty. The optimal thresholding parameter can be searched by the package based on the profile Bayesian information criterion (BIC). The asymptotic validity of the methodology is established in Li et al. (2019 <doi:10.1177/0962280219856238>). The unpenalized nonparametric maximum likelihood estimation for interval censored and possibly left truncated data is also available.

Last updated 2 years ago

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2.15 score 2 stars 14 scripts 336 downloads

YPInterimTesting - Interim Monitoring Using Adaptively Weighted Log-Rank Test in Clinical Trials

For any spending function specified by the user, this package provides corresponding boundaries for interim testing using the adaptively weighted log-rank test developed by Yang and Prentice (2010 <doi:10.1111/j.1541-0420.2009.01243.x>). The package uses a re-sampling method to obtain stopping boundaries at the interim looks.The output consists of stopping boundaries and observed values of the test statistics at the interim looks, along with nominal p-values defined as the probability of the test exceeding the specific observed test statistic value or critical value, regardless of the test behavior at other looks. The asymptotic validity of the stopping boundaries is established in Yang (2018 <doi:10.1002/sim.7958>).

Last updated 6 years ago

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1.70 score 6 scripts 163 downloads

ClinicalTrialSummary - Summary Measures for Clinical Trials with Survival Outcomes

Provides estimates of several summary measures for clinical trials including the average hazard ratio, the weighted average hazard ratio, the restricted superiority probability ratio, the restricted mean survival difference and the ratio of restricted mean times lost, based on the short-term and long-term hazard ratio model (Yang, 2005 <doi:10.1093/biomet/92.1.1>) which accommodates various non-proportional hazards scenarios. The inference procedures and the asymptotic results for the summary measures are discussed in Yang (2018, <doi:10.1002/sim.7676>).

Last updated 6 years ago

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1.70 score 10 scripts 255 downloads